Amylyx Pharmaceuticals Acquires Avexitide for Phase III Trial

Amylyx Pharmaceuticals Acquires Avexitide for Phase III Trial

Marina Silva
1 min read

Amylyx Pharmaceuticals Acquires Avexitide in Strategic Move

Amylyx Pharmaceuticals has made a strategic move by acquiring a Phase III-ready glucagon-like peptide 1 receptor antagonist (GLP1-RA), avexitide, from Eiger BioPharmaceuticals. This acquisition, which was valued at $35.1 million, follows Amylyx's decision to discontinue its ALS drug, Relyvrio, after an unsuccessful Phase III trial, resulting in a significant reduction in its workforce. Despite these setbacks, Amylyx remains dedicated to addressing unmet medical needs, as expressed by its co-CEOs, Joshua Cohen and Justin Klee. The impact of this acquisition was reflected in Amylyx's stock, initially witnessing a drop but subsequently experiencing a 20% rise after the announcement.

Key Takeaways

  • Amylyx's acquisition of avexitide from bankrupt Eiger BioPharmaceuticals for $35.1 million reinforces the company's commitment to developing treatments for unmet medical needs.
  • The Phase III trial for avexitide in hyperinsulinemic hypoglycaemia is scheduled to commence in 2025, with anticipated results in 2026.
  • Following the acquisition announcement, Amylyx's stock initially decreased but later surged by 20%.
  • Previous Phase II studies demonstrated notable reductions in severe hypoglycemic events with avexitide.


Amylyx's acquisition of avexitide signifies a strategic shift following the challenges faced with Relyvrio. This maneuver strengthens Amylyx's pipeline, targeting hyperinsulinemic hypoglycaemia, addressing a significant unmet medical need. The company's flexibility and dedication to advancing in the medical field are evident. While immediate risks are present with the upcoming trials, the successful progression of these trials could redefine treatment approaches and fortify the organization's financial standing.

Did You Know?

  • GLP1-RA (Glucagon-like peptide 1 receptor antagonist): A drug that targets the GLP1 receptor, primarily utilized in the management of type 2 diabetes by regulating insulin release and diminishing blood glucose levels.
  • Hyperinsulinemic Hypoglycaemia: A medical condition characterized by low blood sugar levels (hypoglycemia) due to excessive insulin production, often observed in patients with insulinomas or following pancreatic surgery.
  • Phase III Clinical Trial: An essential stage in the drug development process, where a pharmaceutical company assesses a new drug on a larger population to ascertain its efficacy and safety before seeking regulatory approval.

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