AstraZeneca's Tagrisso Shows Groundbreaking Results in Treating Non-Small Cell Lung Cancer

AstraZeneca's Tagrisso Shows Groundbreaking Results in Treating Non-Small Cell Lung Cancer

Sakura Tanaka
2 min read

AstraZeneca's Tagrisso Shows Promise in Treating Lung Cancer

AstraZeneca's Tagrisso (osimertinib) showcased significant advancements in progression-free survival (PFS) during the recent American Society of Clinical Oncology (ASCO) Annual Meeting. The LAURA study compared Tagrisso to platinum-based chemotherapy, revealing a notable PFS of 39.1 months for Tagrisso versus 5.6 months for the placebo, with a hazard ratio of 0.16. This breakthrough could potentially revolutionize the standard of care for stage III epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC) patients who are ineligible for resection. Additionally, the study highlighted a lower incidence of new brain lesions in the Tagrisso group, indicating its potential to become the new standard of care for this patient segment. The global sales forecast for Tagrisso is expected to rise to $7.4 billion by 2030.

Key Takeaways

  • Tagrisso significantly improved progression-free survival in stage III EGFRm NSCLC patients compared to placebo (39.1 months vs. 5.6 months).
  • The LAURA study showed a higher objective response rate for Tagrisso (57%) compared to placebo (33%).
  • Median duration of response was longer with Tagrisso (36.9 months) than with placebo (6.5 months).
  • Brain lesion development was lower in Tagrisso group (8%) compared to placebo (29%).
  • The LAURA study suggests Tagrisso could become the new standard of care for unresectable stage III EGFRm NSCLC.


The LAURA study's findings on Tagrisso's efficacy in stage III EGFRm NSCLC could redefine treatment protocols, impacting AstraZeneca's revenue positively as predicted sales surge to $7.4 billion by 2030. Patients and healthcare systems may benefit from prolonged PFS and reduced brain lesion incidence, though long-term Tagrisso use raises concerns about drug resistance and treatment sustainability. Competitors in the oncology sector may face increased pressure to innovate, while regulatory bodies could expedite approvals for similar therapies. This shift underscores the growing importance of targeted therapies in cancer care, influencing future research and drug development strategies.

Did You Know?

  • Progression-Free Survival (PFS): In the context of the LAURA study, PFS for Tagrisso was significantly longer (39.1 months) compared to the placebo (5.6 months), indicating that the drug delays disease progression effectively.
  • Epidermal Growth Factor Receptor Mutated (EGFRm) Non-Small Cell Lung Cancer (NSCLC): This specific type of lung cancer involves a mutation in the epidermal growth factor receptor gene, leading to rapid cell growth and division. Targeted therapies like Tagrisso are particularly effective for this subset of lung cancers.
  • Hazard Ratio (HR): A hazard ratio of 0.16 means that the risk of disease progression in patients taking Tagrisso is 16% of the risk in patients taking a placebo, indicating a strong protective effect of Tagrisso against disease progression.

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