Oxolife's OXO-001 Shows Promising Results in Improving Fertility

Oxolife's OXO-001 Shows Promising Results in Improving Fertility

Alejandra Delgado
2 min read

Oxolife's Non-Hormonal Fertility Pill Shows Positive Phase II Results

Spanish biotech company Oxolife has revealed encouraging Phase II findings for its non-hormonal fertility medication, OXO-001, aimed at enhancing pregnancy and live birth rates in women undergoing IVF. The pill, taken twice daily, works to improve the uterine endometrium's receptivity to embryo implantation. The trial involved 96 women aged up to 40, utilizing donor eggs for single embryo transfers.

Results from the OXOART2 trial, presented at the ESHRE 40th Annual Meeting in Amsterdam, demonstrated a 10.6% increase in pregnancy rates and a 6.9% rise in live birth rates with OXO-001 compared to a placebo. Early pregnancy confirmation rates were notably higher in the treatment group at 75.9% versus 52.4% in the placebo group. Five weeks post-transfer, pregnancy rates with a fetal heartbeat were 50% for OXO-001 and 35.7% for the placebo.

Key Takeaways

  • Oxolife's fertility pill OXO-001 boosts pregnancy and live birth rates by 10.6% and 6.9% respectively in Phase II trial.
  • The non-hormonal pill aims to enhance embryo implantation in the uterus.
  • Phase II OXOART2 trial involved 96 women using donor eggs for IVF.
  • Planned Phase III trial will include women using their own eggs.
  • Female infertility market projected to reach $2.3 billion by 2033 across major markets.


Oxolife's breakthrough with OXO-001 could reshape the $2.3 billion female infertility market. Direct beneficiaries include IVF clinics and patients, with potential share gains for Oxolife. Indirectly, competitors may accelerate R&D to counter this advancement. Short-term, Oxolife's stock could surge, attracting investor interest. Long-term, broader market adoption could depend on Phase III results and regulatory approvals, influencing global fertility treatment standards and patient outcomes.

Did You Know?

  • Non-hormonal fertility pill: A medication designed to improve fertility without the use of hormones, which can often have side effects and complexities in dosage and timing. Non-hormonal approaches aim to enhance natural biological processes, such as improving the receptivity of the uterine lining (endometrium) to embryo implantation.
  • Uterine endometrium's receptivity: The endometrium is the inner lining of the uterus, which plays a crucial role in pregnancy by providing a suitable environment for an embryo to implant and grow. Enhancing its receptivity means optimizing its structure and function to increase the likelihood of successful implantation and subsequent pregnancy.
  • IVF (In Vitro Fertilization): A complex series of procedures used to help with fertility or prevent genetic problems and assist with the conception of a child. During IVF, mature eggs are collected from ovaries and fertilized by sperm in a lab, with the resulting embryos transferred to the uterus.

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