Repare Therapeutics Expands NSCLC Trial with Camonsertib

Repare Therapeutics Expands NSCLC Trial with Camonsertib

Elena Santiago
1 min read

Repare Therapeutics Initiates NSCLC Expansion of Camonsertib Trial

Repare Therapeutics has launched the expansion of its Phase I/II TRESR clinical trial for camonsertib, focused on treating non-small cell lung cancer (NSCLC). The trial will examine the safety and efficacy of camonsertib as both a standalone treatment and in combination with other therapies. The company aims to recruit up to 20 patients with ATR-inhibitor-sensitising mutations to ascertain the drug's effectiveness at the recommended Phase II dose. Camonsertib offers a promising oral therapy alternative for patients with recurrent NSCLC, where treatment options are limited, and is expected to report trial data from this expansion in 2025. Repare Therapeutics leverages its advanced CRISPR-enabled SNIPRx platform to develop targeted cancer treatments and is actively committed to innovative cancer therapies.

Key Takeaways

  • Repare Therapeutics has initiated the NSCLC expansion of its Phase I/II TRESR clinical trial for camonsertib.
  • The trial aims to assess camonsertib's safety, tolerability, and anti-tumor activity, both as a monotherapy and in combination with other treatments.
  • Up to 20 patients with ATR-inhibitor-sensitising mutations will be recruited for the NSCLC expansion.
  • Camonsertib provides an oral therapy alternative for recurrent NSCLC with a well-established safety profile.
  • Trial data from the camonsertib monotherapy NSCLC expansion is expected to be reported in 2025.


Repare Therapeutics' expansion of the camonsertib trial for NSCLC addresses a critical need for novel treatments in recurrent cases. The focus on ATR-inhibitor-sensitising mutations suggests a targeted approach, potentially benefiting patients with limited options. This development could impact the biotech sector, influencing investment and competition in targeted cancer therapies. Short-term, the trial's success may boost Repare's stock and attract further investment. Long-term, if camonsertib proves effective, it could reshape NSCLC treatment protocols, enhancing patient outcomes and potentially setting a new standard in precision oncology.

Did You Know?

  • ATR-inhibitor-sensitising mutations: These genetic mutations in cancer cells make them particularly susceptible to treatment with ATR inhibitors, disrupting the DNA repair process and leading to cell death.
  • CRISPR-enabled SNIPRx platform: SNIPRx is a proprietary genome-wide CRISPR-Cas9-based screening platform that allows for the precise identification of gene targets to selectively kill cancer cells.
  • Phase I/II TRESR clinical trial: This trial combines safety, dosage assessment, and efficacy evaluation before larger Phase III trials, ensuring thorough testing in a controlled setting.

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